Precision Radiomolecular Oncology:
Challenging the Classical Statistical
Evidence-Based Medicine
7
Baljinder Singh, Harneet Kaur, Ashwin Singh Parihar, Ankit Watts,
and Vikas Prasad
Abstract
Evolution and survival instinct have been the principal forces behind the existence of
any biological system in nature. Homo sapiens are no exception to it. Cancer cells,
evolving from the “normal cells” of Homo sapiens are thus governed by the same
rules. This is one of the reasons why, despite the advances in modern oncology, cure
is not achievable in several cancers. Driven by the challenges posed by cancerous
tissue, several new multipronged strategies have been envisaged. At the center of the
new strategical development in oncology is the understanding that we need to
outsmart cancer cells by evolving much powerful diagnostic tools and highly
specific targeted therapy. Nuclear medicine, at the forefront of precision theranostics,
has realized the challenges and offered appropriate and well-timed diagnostic and
therapeutic options to improve and optimize patient management. This chapter will
highlight the pitfalls of classical evidence-based medicine and show the way forward
to more individualized/personalized approach, i.e., by amalgamating radiomolecular
oncology with specific molecular profiling and gene panels, texture analyses, and
better understanding of the cancer phenome.
Keywords
Evolution and survival instinct · Biological system · Modern oncology ·
Therapeutic options · Personalized approach · Radiomolecular oncology · Cancer
phenome
B. Singh (*) · H. Kaur · A. S. Parihar · A. Watts
Department of Nuclear Medicine, Postgraduate Institute of Medical Education and Research,
Chandigarh, India
e-mail: drbsingh5144@yahoo.com
V. Prasad
Department of Nuclear Medicine, University Hospital Ulm, Ulm, Germany
# The Author(s), under exclusive license to Springer Nature Singapore Pte
Ltd. 2022
R. C. Sobti, N. S. Dhalla (eds.), Biomedical Translational Research,
https://doi.org/10.1007/978-981-16-9232-1_7
97